Large Heading
PUBLICATIONS
Sponchiado M, Bonilla AL, Mata L, Jasso-Johnson K, Liao YJ, Fagan A, Moncada V, Reznikov LR. (2023) Club cell CREB regulates the goblet cell transcriptional network and pro-mucin effects of IL-1B. Front Physiol. 2023 Dec 20;14:1323865. doi: 10.3389/fphys.2023.1323865. eCollection 2023.
Pelot NA, Vaseghi M, Reznikov L, Osborne PB, Conde SV. (2023) Editorial: Multiscale anatomy and biophysics of the autonomic nervous system: implications for neuromodulation. Front Neurosci. 2023 Nov 1;17:1289177. doi: 10.3389/fnins.2023.1289177. eCollection 2023.
Marciante AB, Lurk C, Mata L, Lewis J, Reznikov LR, Mitchell GS. (2023) Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice. Front Physiol. 2023 Sep 21;14:1272980. doi: 10.3389/fphys.2023.1272980. eCollection 2023.
Madala SK, Reznikov LR. Lung Fibrosis Finds an Unsung Hero in Neuropeptide Y. (2022) Am J Respir Cell Mol Biol. Dec;67(6):613-614. doi: 10.1165/rcmb.2022-0375ED.
Sponchiado M, Liao YSJ, Reznikov LR (2022). Identification of cholinergic cells with chemosensory traits in the porcine uterus. Cell Tissue Res. Apr;388(1):33-47. doi: 10.1007/s00441-022-03585-1. Epub 2022 Jan 27.
.
Reznikov LR. To alkalinize or acidify, that is the question (2021). Biophysical Journal. 5436-5437. doi: 10.1016/j.bpj.2021.11.012.
Meyerholz DK, *Reznikov LR (2021). Influence of SARS-CoV-2 on airway mucus production: a review and proposed model. Veterinary Pathology. doi: 10.1177/03009858211058837. *corresponding author.
Bouzek DC, Abou Alaiwa MH, Adam RJ, Pezzulo AP, Reznikov LR, Cook DP, Pescozo MA, Eyck PT, Wu C, Gross TJ, Hornick DB, Hoffman HA, Meyerholz DK, Stoltz DA (2021). Early lung disease exhibits bacterial-dependent and independent abnormalities in cystic fibrosis pig. American Journal of Respiratory and Critical Critical Care Medicine. In press. doi: 10.1164/rccm.202102-0451OC.
Sponchiado MS, Liao YSJ, Atanasova KR, Collins EN, Schurmann V, Bravo, L, Reznikov LR (2021). Overexpression of substance P in pigs airways increases MUC5AC through a NF-kb pathway. Physiological Reports. (3):e14749. doi:10.14814/phy2.14749. 2021.
Saad MZH, Xiang L, Liao YSJ, Reznikov LR, Du J (2021). The underlying mechanism of modulation of transient receptor potential melastatin 3 by protons. Frontiers in Pharmacology.https://doi.org/10.3389/fphar.2021.632711.
Reznikov LR (2020). From apples to airways – why gravity matters. Experimental Physiology (commissioned). doi: 10.1113/EP089333. Online ahead of print.
Reznikov LR*, Norris MH*, Vashisht R(&), Bluhm A, Li D, Liao YSJ, Brown A, Butte A, Ostrov DA# (2020). Identification of antiviral antihistamines for COVID-19 repurposing. Biochemical Biophysical Research Communications. S0006-291X(20)32140-9. doi: 10.1016/j.bbrc.2020.11.095. Online ahead of print. PMCID: PMC7713548.
Reznikov LR (2020). PKCe-sensing in the carotid body – a new target for asthma? Journal of Physiology (commissioned).doi: 10.1113/JP281080. Online ahead of print.
Liao YSJ#, Collins EN#, Guevara MV, Schurmann V, Atanasova KR, Bravo L, Sponchiado M, Hoegger MJ, Reznikov LR (2020). Airway cholinergic history modifies mucus secretion properties to subsequent cholinergic challenge in diminished chloride and bicarbonate conditions. Experimental Physiology.105(10):1673-1683. doi: 10.1113/EP088900.
Liao YSJ#, Kuan SP#, Guevara MV#, Collins EN%, Atanasova KR%, Dadural JS, Vogt KM, Schurmann V, Bravo L, Eken E, Sponchiado M, Reznikov LR. (2020). Acid exposure impairs mucus secretion and disrupts mucociliary transport in neonatal piglet airways. AJP-Lung. Am J Physiol Lung Cell Mol Physiol. 2020 Mar 11. doi: 10.1152/ajplung.00025.2020
Kuan SP, Atanasova KR, Guevara MV, Collins EN, Reznikov LR (2019). Long-term culturing of porcine nodose ganglia. Journal of Neuroscience Methods. Dec 9;332:108546. doi: 10.1016/j.jneumeth.2019.108546
Atanasova KR, Reznikov LR (2019) Strategies for Measuring Airway Mucus and Mucins. Respiratory Research. Nov 21;20(1):261. doi: 10.1186/s12931-019-1239-z
Kuan SP, Liao YSJ, Davis KM, Messer JG, Zubcevic J, Aguirre JI, Reznikov LR (2019)Attenuated amiloride-sensitive current and augmented calcium-activated chloride current in marsh rice rat (Oryzomys palustris) airways. iScience. Sep 27;19:737-748. doi: 10.1016/j.isci.2019.08.011
Yang T, Magee KL, Colon-Perez LM, Larkin R, Liao YSJ, Balazic E, Cowart JR, Arocha R, Redler T, Febo M, Vickroy T, Martyniuk J,Reznikov LR, Zubcevic J.(2019) Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats. Acta Physiologica. Jan1 18:e13256. Doi: 10.1111/apha.13256.
Jiron JJ, Mendieta C, Castillo, EJ, Abraham AM, Messer JG, Malphurs WL, Malinowski C, Grove K,Reznikov LR, Zubcevic J, Aguirre JI.(2019) Comparison of Isoflurane, Ketamine-dexmedetomidine and ketamine-xylazine for general anesthesia during oral procedures in rice rats (oryzomys palustris). JAALASJan 1;58(1):40-49.PMCID: PMC6351055.
Reznikov LR,Liao YSJ,Gu T, Davis K, Kuan SP, Atanasova KR, Dadural JS, Collins EN, Guevara MV, Vogt KM(2019) Sex-specific airway hyperreactivity and sex-specific transcriptome remodeling in neonatal piglets challenged with intra-airway acid. AJP-Lung. Jan 1;316(1):L131-L143. doi: 10.1152/ajplung.00417.2018. Epub 2018 Nov 8. PMCID: PMC6383496.
Meyerholz DK,Beck, AP, Goeken A, Leidinger MR, Ofori-Amanfo GK, Brown HC, Businga TR, Stoltz DA, Reznikov LR,Flaherty HA(2018) Glycogen depletion can increase the specificity of mucin detection in airway tissues. BMC Research.Oct 25;11(1):763. PMCID: PMC6203197.
Atanasova KR, Reznikov LR(2018) Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Respiratory Research. Aug 6; 19(1):149. PMCID: PMC6090699.
Dadural JS,Reznikov LR(2018) Interest in and awareness of French President Emmanuel Macron’s “Make our Planet Great Again” Initiative. Social Sciences.June 25; 7(7), 102.
Reznikov LR, Meyerholz DK, Abou Alaiwa MHA, Kuan SP, Liao YSK, Bormann N, Bair, T, Price M, Stoltz, DA, Welsh MJ. (2018) Vagal Ganglia Transcriptome Identifies Candidate Therapeutics for Airway Hyperreactivity. AJP-Lung.Aug 1;315(2):L133-L148. PMCID: PMC6139658.
Reznikov LR, Meyerholz DK, Kuan SP, Guevara M, Atanasova KR, Abou Alaiwa, MHA. Solitary Cholinergic Stimulation Induces Airway Hyperreactivity and Transcription of Distinct Pro-inflammatory Pathways. (2018) Lung.Apr; 196(2):219-229. PMCID: PMC5975219.
Mao SF, Shah AS, Moninger TO, Ostedgaard LS, Lu L, Tang XX, Thornell IM,Reznikov LR, Ernst S, Karp PH, Tang P, Keshavjee S, Abou Alaiwa, MH, Welsh MJ. (2018) Motile Cilia of Human Airway Epithelia Contain Hedgehog Signaling Components that Mediate Noncanonical Hedgehog Signaling. Proceedings of the National Academy of Sciences. Feb 6; 115 (6): 1370-1375. PMCID: PMC5819449.
Meyerholz DK, Reznikov LR. (2017) Simple and Reproducible Approaches for the Collection of Select Porcine Ganglia. J Neuroscience Methods.Sept, 1; 289:93-98.
Reznikov LR. (2017) Cystic Fibrosis and the Nervous System. Chest.May; 151(5):1147-1155. PMCID: PMC5472519.
Reznikov LR,Meyerholz DK, Ryan AJ, Abou Alaiwa MH, Jaffer O, Michalski AS, Powers LP, Price MP, Stoltz DA, Welsh MJ. (2016) Acid-sensing ion channel 1a Contributes to Airway Hyperreactivity in Mice. PLOS ONE.Nov 7;11(11):e0166089. PMCID: PMC5098826.
Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa MH, Ernst SE, Karp PK, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ. (2016) Airway Acidification Initiates Host Defense Abnormalities in Cystic Fibrosis Mice. Science. 351(6272):503-7. PMCID: PMC4852973.
Li K, Wohlford-Lenane C, Perlman S, Jewell AK,Gibson-Corley KN, Reznikov LR, Meyerholz DK,McCray PB. (2016) Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4.Journal of Infectious Diseases. 213(5):712-22. PMCID: PMC4747621
Cook DP, Rector MV, Bouzek DC, Michalski AP, Gansemer ND, Reznikov LR, Stroik MR, Ostedgaard LS,Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow C, Stoltz DA. (2016) CFTR in sarcoplasmic reticulum of airway smooth muscle: implications for airway contractility. American Journal of Respiratory and Critical Care Medicine. 193(4):417-26. PMCID: PMC4803085
Meyerholz DK, Lambertz A, Reznikov LR,Ofori-armanfo G,Karp PH,McCray PB, Welsh MJ, Stoltz DA. (2016) Immunohistochemical detection of porcine markers for translational studies of lung diseases in pigs and humans. Toxicologic Pathology. ;44(3):434-41.PMCID: PMC4805467
Uc A, Olivier AK, Griffin MA Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderon OG, Abu-El-Haija M, Pezzulo AA,Reznikov LR, Hoegger MJ, Rector MV,Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW(2015) Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clin Sci.128(2):131-42.PMCID: PMC4346161
Du JY,Reznikov LR,Welsh MJ. (2014) Expression and Activity of Acid-Sensing Ion Channels in the Mouse Pituitary. PLoS ONE. 9(12):e115310. PMCID: PMC4266673.
Abou Alaiwa MH, Reznikov LR, Gansemer N, Sheets K, Horswill A, Stoltz DA, Zabner J, and Welsh MJ. (2014) pH modulates the activity and synergism of the airway antimicrobials B-defensin-3 and LL37.Proceedings of the National Academy of Sciences. 30;111(52):18703-8. PMCID: PMC4284593.
Du JY,Reznikov LR, Price MP, Zha XM, Yuan L, Moninger TO, Wemmie JA, Welsh MJ. (2014) Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proceedings of the National Academy of Sciences.11(24):8961-6. PMCID: PMC4066526.
Reznikov LR, Abou Alaiwa MH, Dohrn CL, Gansemer N, Diekema DJ, Stoltz DA, Welsh MJ. (2014) Antibacterial properties of the CFTR potentiator ivacaftor. Journal of Cystic Fibrosis.pii: S1569-1993(14)00044-7. PMCID: PMC4718582.
Price MP, Gong H, Parsons MG, Kundert JR,Reznikov LR,Bernardinelli L, Chaloner K, Buchanan GF, Wemmie JA, Richerson GB, Cassell MD, Welsh MJ (2013) Localization and Behaviors in Null Mice Suggest that ASIC1 and ASIC2 Modulate Responses to Aversive Stimuli. Genes, Brain and Behavior.13(2):179-94. PMCID: PMC3998777
Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson, IV GA, Hoffman EA, Chang EH, Zabner J, McCray, Jr. PB, Prather RS, Meyerholz DK, Welsh MJ. (2013) Intestinal CFTR Expression Alleviates Meconium Ileus in Cystic Fibrosis Pigs. J Clin Invest.Jun 3;123(6):2685-93. PMCID: PMC3668832.
Reznikov LR,Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y, Du JY, Hildebrand MS, Smith RJ, Randak CO, Stoltz DA, Welsh MJ(2013) CFTR-Deficient pigs display peripheral nervous system defects at birth. Proceedings of the National Academy of Sciences. 110(8):3083-3088. PMCID: PMC3581923(Selected as cover).
*Piroli GG, *Reznikov LR,Grillo CA, Hagar JM, Fadel JR, Reagan LP. (2012) Tianeptine modulates amygdalar glutamate neurochemistry and synaptic proteins in rats subjected to repeated stress. Experimental Neurology. 241:184-93.(*co first-author).
Reagan LP,Reznikov LR,Evans AN, Gabriel-Gracia C, Mocaer E, Fadel JR. (2012) The Antidepressant Agomelatine Inhibits Stress-Mediated Changes in Amino Acid Efflux in the Rat Hippocampus and Amygdala. Brain Research. 1466:91-8.
Change EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR,Sieren J, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB, Stoltz DA, Welsh MJ, Zabner J. (2012). Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. Laryngoscope. 122(9):1898-905. PMCID: PMC3449319.
Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rohklina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB, Zabner J, Welsh MJ and Stoltz DA (2011) The DF508 mutation causes misprocessing of CFTR in pigs and produces the gastrointestinal and lung disease of Cystic Fibrosis. Science Translational Medicine.3: (74): 74ra24. PMCID: PMC 3119077.
*Rogan MP, *Reznikov LR,Pezullo AP, Ganesemer N, Samuels M, Prather R, Zabner J, Fredericks DC, McCray PB. Welsh MJ and Stoltz DA. (2010) Pigs and humans with cystic fibrosis have reduced IGF-1 levels at birth. Proceedings of the National Academy of Sciences. 107 (47): 20571-5. PMCID:PMC2996661.(*co first-author).
Chen JH, Stoltz DA, Karp PH, Ernst SE, Pezzulo AP, Moninger TO, Rector MV, Reznikov LR,Lanspach JL, Chaloner K, Zabner J, Welsh MJ. (2010) Loss of anion transport without alterations in sodium absorption characterize porcine cystic fibrosis airway epithelia. Cell.143 (6): 911-23.PMCID: PMC3057187.
Reznikov LR,Pasumarthi RK, Fadel JR. (2009) Caffeine elicits c-Fos expression in horizontal diagonal band cholinergic neurons. Neuroreport. 20 (18):1609-12.
Zha XM, Costa V, Harding A, Reznikov L,Benson C, Welsh M. (2009) ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95. Journal of Neuroscience. 29(26):8438-46. PMCID: PMC2734339.
Reznikov LR,Reagan LP, Fadel JR. (2009) Effects of acute and repeated restraint stress on GABA efflux in the rodent basolateral and central amygdala. Brain Research. 1256:61-8.
Reznikov LR, Reagan LP, Fadel JR. (2008) Activation of phenotypically distinct neuronal subpopulations in the rat basolateral amygdala following acute and repeated stress. Journal of Comparative Neurology. 508:458-472.
Grillo CA, Tamashiro KL, Piroli GG, Gass JT, Reznikov LR,Smith A, Wilson SP, Sakai RR, Reagan LP. (2007) Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiology and Behavior. 4:691-701. PMCID: PMC2129218.
Reznikov LR, Grillo CA*, Piroli GG, Pasumarthi R, Reagan LP, Fadel JR. (2007) Acute stress mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment. European Journal of Neuroscience.10:3109-14.(*co first-author)
Piroli GG, Grillo CA, Reznikov LR,Adams S, McEwen BS, Charron MJ,Reagan LP. (2007) Corticosterone impairs insulin stimulated translocation of GLUT4 in the rat hippocampus. Neuroendocrinology. 2:71-80.
Reagan LP, Hendry RM, Reznikov LR,Piroli GG, Wood GE,McEwen BS, Grillo CA. (2007) Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala. European Journal of Pharmacology. 1-3:68-75.
Pasumarthi R, Reznikov LR, Fadel J. (2006) Activation of orexin neurons by acute nicotine. European Journal of Pharmacology.1-3:172-6.
Winocur G, Greenwood CE,Piroli GG, Grillo CA, Reznikov LR, Reagan LP, McEwen BS. (2005) Memory Impairment in Obese Zucker Rats: An Investigation of Cognitive Function in an Animal Model of Insulin Resistance and Obesity. Behavioral Neuroscience. 5:1389-95.
Grillo CA, Piroli GG, Wood GE, Reznikov LR,McEwen BS, Reagan LP. (2005) Radioimmunocytochemical analysis of synaptic proteins provides new insight into morphological plasticity in the rat hippocampus. Neuroscience. 2:477-486.
Fadel J, Pasumarthi R, Reznikov LR. 2005) Stimulation of cortical acetylcholine release by orexin A. Neuroscience.2:541-7.